Projects

Sequence programming, Image reconstruction, fMRI

SMS-EPI fMRI

A Pulseq SMS-EPI fMRI sequence and reconstruction protocol, suitable for multi-site, multi-vendor studies.

Sequence programming, Image reconstruction, Diffusion

Pulseq-diffusion

MatLab code to create diffusion EPI sequences to be run using the Pulseq sequence programming environment

Sequence programming, Image reconstruction, fMRI, Diffusion

High-resolution multi-shot readout-segmented EPI

This is a open source project for a ISMRM 2024 abstract and its submitted MRM paper under review. It is a high-resolution multi-shot readout-segmented EPI sequence with shot-to-shot phase fluctuations estimated from overlapped k-space regions between segments, instead of relying on external 2D navigators. The scripts include Pulseq sequence generation, example data, and reconstruction script, all in MATLAB. I aim to have a associated link available for the ISMRM diffusion workshop 2025 (ddl. submission Dec 6th 2024), and later a few modifications are expected to improve its user-friendliness.

Quantitative MRI

Rapid, open-source, cross-platform 3D multiparametric mapping for multisite neuroimaging

Open-source, vendor-agnostic, rapid 3D multiparametric mapping provided T1 and T2 relaxation times with less than a 4.0% variation across different scanners, software, and vendors, with improved cross-vendor reproducibility for both in phantom and in vivo data compared to vendor-native implementations.

Sequence programming, Pulseq interpreter

Pulseq on GE v2

Community-developed Pulseq interpreter for GE scanners.

Sequence programming

Pypulseq

Python-based, vendor-neutral pulse sequence programming

Sequence programming, Image reconstruction, Image processing, Quantitative MRI

Free-breathing fat quantification with flip angle modulation

This project implements a flip angle modulated, 2D-encoded sequential Cartesian gradient echo acquisition for high-SNR, motion-robust fat (PDFF) and iron (R2*) quantification, originally designed for use in the liver. After confounder-corrected fitting for PDFF and R2*, initial results show strong reproducibility across vendors, scanner models, and field strengths.

Sequence programming, Image reconstruction, Diffusion

PRIME: Phase Reversed Interleaved Multi-Echo acquisition enables highly accelerated distortion-free diffusion MRI

Phase-reversed interleaved multi-echo acquisition (PRIME) for rapid, high-resolution, and distortion-free dMRI

Sequence programming, Image reconstruction, Quantitative MRI

MIMOSA: Multi-parametric Imaging using Multiple-echoes with Optimized Simultaneous Acquisition for highly-efficient quantitative MRI

MIMOSA enables highly-efficient T1, T2, T2*, PD, QSM, para- and diamagnetic susceptibility mapping.

Sequence programming

Shuffle3DGRE

An open (via Pulseq) 3D gradient echo MRI sequence supporting multiple Cartesian trajectory options for reducing physiological fluctuation artifacts

Sequence programming, Image reconstruction, fMRI

Fast-fMRI: Random 3D-EPI Acquisition + Locally Low-Rank Reconstruction

A set of tools for vendor-agnostic, highly accelerated fMRI acquisition and reconstruction.

Sequence programming

Open-MOLLI

Open-source Myocardial T1 mapping (Open-MOLLI) developed using Pulseq is an inversion recovery T1 mapping sequence with a triggering scheme 5(3)3. Open-MOLLI provides the groundwork for standardization and for further developments such as adding simultaneous multi-slice excitation (SMS) capabilities to Open-MOLLI myocardium T1 mapping.

Sequence programming, Image reconstruction

Looping Star

Looping Star pulse sequence and reconstruction pipeline in Pulseq

Sequence programming, Image reconstruction, Image processing, Simulations, Protocol workflow, Diffusion, Quantitative MRI

OpenMRF

A Pulseq-based Magnetic Resonance Fingerprinting Framework